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Brainteaser is a data science project that seeks to exploit the value of big data to support patients with amyotrophic lateral sclerosis and multiple sclerosis and their clinicians. Taking advantage of cost-efficient sensors and apps, Brainteaser will integrate large, clinical datasets that host both patient-generated and environmental data. The data collected will help develop artificial intelligence tools that shed light on disease mechanisms, promote early detection and prevent the onset of patient complications. The creation of such tools will respond to current needs for precision medicine. Technical solutions developed by Brainteaser will follow agile and user-centred approaches, accounting for the functional, medical, psychological, and societal needs of specific users.