PPD Inc

The development of effective vaccines is among the greatest advancements in public health to combat infectious diseases. It is a complex multi-year and multi-stakeholder process that requires well-designed strategy, partnership, and preparedness among the clinical, operational, and laboratory experts. In this webinar, hear from experts on the importance of having an integrated approach among the clinical and laboratory teams well before the protocol development and how robust laboratory and IT capabilities along with innovative automation help improve the efficiency of vaccine development.

Discover an informative webinar exploring the impact of osmolality in bioprocessing and in correlation with immunoglobulin G (IgG) production. Osmolality is described as the measurement of the contribution of all the dissolved solutes to the osmotic pressure of a solution. In biopharma, osmolality is usually used as a critical quality control check for cell culture media, buffers, and formulated drug products. It is also used as a critical process parameter during upstream cell culture and downstream filtration.The Cell Technology group at the National Institute for Bioprocessing Research and Training (NIBRT) focuses on the development of bioprocesses using mammalian cells to produce recombinant proteins, monoclonal antibodies, and viral vaccines. There is also a particular interest in the bioprocess conditions that can be used to control the biochemical structure and the post-translational modifications of glycoproteins and hence the quality of biopharmaceuticals.Osmolality is routinely used in the Cell Technology group as a QC tool, similar to the routine application in the biopharma industry. However, osmolality is applied as an experimental measurement to correlate with IgG production, nutrient depletion studies, and bioprocessing applications.In this webinar, the featured speaker will describe the impact of osmolality assessment in correlation with IgG production when examining the effect of plant protein hydrolysates as additives, in a media development project. When examining the effect of changing media composition to affect IgG glycosylation, osmolality was tracked and correlated with growth and productivity.In the investigation into the recoverability of cells at various stages of nutrient depletion, osmolality measurements were utilized to correlate the suitability of culture conditions in 're-fed' media, vs. controls of complete media. These preliminary investigations are in the process of being scaled up to the bioreactor level (bench scale) where osmolality validation will be used on samples taken in at-line process analytical technology (PAT) instrumentation development.Join this webinar to gain insights into osmolality in correlation with IgG production in a media development project.

Discover a groundbreaking webinar delving into advancements in antibody-drug conjugates (ADCs) and related patent filings. Antibody-drug conjugates are among the most promising drug classes in oncology...

Discover a groundbreaking webinar delving into the importance of patient-centricity in hematological malignancy clinical trials. At the heart of every therapeutic breakthrough are patients — and their loved ones — whose noble contributions to medical research pave the path to market for innovative treatments that improve outcomes and quality of life. In hematological malignancies — where global incidence is increasing and the median age for most diseases is 65-70 years of age — a patient-centered mindset is essential for addressing and overcoming barriers to clinical trial participation for this fragile patient population. Increasingly, sponsors and regulators are emphasizing the importance of enhancing the patient experience in clinical trials to increase participation and generate meaningful data that truly reflects patients’ needs and preferences. When implemented successfully, patient-centric strategies promote higher engagement and, ultimately, improved healthcare outcomes. Join this webinar to gain insights into: Drivers and benefits of patient centricity in the clinical trial landscape, Why patient-centric approaches are important in populations with hematological malignancies, Regulatory perspectives on the patient experience in clinical trials, How to design and execute patient-centric hematological malignancy clinical trials, with real-life examples

Mushrooms have been used in medicinal and spiritual practices by Indigenous cultures around the world. This webinar will discuss the pharmacology and chemistry of psychedelic alkaloids found in the fungi kingdom and their use in psychedelic medicine.